Marina Noris
KI Best Reviewer
KI reviewers were evaluated by the number of reviews they completed in 2023, the quality of each review as assessed by the Kidney International Associate Editors, and the length of time manuscripts were under review.
Dr. Marina Noris is the Head of the Laboratory of Immunology and Genetics of Transplantation and Rare Diseases (January 2000), and the Head of the Center of Human Genetics at the Mario Negri Institute, in Bergamo, Italy (January 2023).
Marina Noris has in-depth expertise in rare genetic kidney diseases, particularly in rare complement-related kidney diseases. In this field, she contributed to discover the genetic causes of atypical hemolytic uremic syndrome (aHUS), describing the mutations in genes encoding complement regulatory proteins, factor H, membrane cofactor protein, and thrombomodulin and their functional consequences. Her discoveries have been described in a number of publications in high impact journals, including the Lancet, Blood, the Journal of the American Society of Nephrology and the New England Journal of Medicine. Her research also clarified that the specific genetic defect has a great impact on the clinical course of this disease and on the risk of disease recurrence after kidney transplantation and contributed to the achievement of a specific cure with the anti-C5 antibody Eculizumab.
In 2010, her laboratory was accredited by Regione Lombardia and the Italian National Health Service as a reference center for biochemical and genetic diagnostic tests in patients with aHUS and TTP. In 2015, the accreditation was extended to C3G/MPGN, steroid resistant nephrotic syndrome, and PKD. On July 2017, the laboratory received the ISO 9001/2008 certification for biochemical and genetic analysis in patients with rare diseases.
Dr. Noris’ group also discovered the genetic cause of very rare kidney disease, the glomerulopathy with fibronectin deposits and a new genetic form of childhood onset familial FSGS associated with mutation in the myosin 1E gene. Using next generation sequencing technology, her group has identified a new genetic form of recessive steroid resistant nephrotic syndrome (SRNS) associated with mutations in the myosin 1 E gene.
Dr. Noris has published around 250 publications and has an H-index: 85 (Google scholar) > 25,000 citations.
The KI-ISN Early Career Researchers and Best Reviewers will be acknowledged in the Editors’ Pick of ISN Journals: KI and KIR session taking place Monday, April 15, 2024, from 9-10:30 am in Hall C2.