REGISTRATION
ISN South Asia Regional Board Webinar:
ANCA-associated vasculitis – current understanding and treatment
Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of rare autoimmune conditions that cause inflammation of blood vessels with various manifestations mainly involving the kidney and lung. The incidence is 10-20 cases per million population, mainly affecting people in the 5th decade of life.
ANCA-associated Vasculitis includes three main diseases: granulomatosis with polyangiitis, microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis. Kidney involvement manifests as rapidly progressive renal failure and crescentic glomerulonephritis. Delay in treatment may be life-threatening and may result in permanent renal failure. Treatment includes induction regimens with steroids, followed by a maintenance regimen. Plasmapheresis during the induction phase remains controversial with differing evidence in MEPEX and PLEXIVAS trials. The webinar will explore pros and cons of each aspect of management.
Learning Objectives:
- Pathogenesis of ANCA-associated vasculitis
- Outlines for evaluation of ANCA vasculitis.
- Management options with outcomes for ANCA-associated vasculitis
Further Reading:
- Kitching, A.R., Anders, HJ., Basu, N. et al. ANCA-associated vasculitis. Nat Rev Dis Primers 6, 71 (2020). https://doi.org/10.1038/s41572-020-0204-y
- KDIGO Clinical Practice Guideline on Glomerular Diseases 2020