aHUS (atypical hemolytic uremic syndrome) is a very rare genetic disease that causes tiny blood clots to form in blood vessels, blocking blood flow to important organs. aHUS can cause kidney failure, heart disease and other serious health problems. There is no known cure for aHUS, but it can be treated.
New! Narrated Animation on Complement System Dysregulation and Its Impact on the Kidney–Watch it Now!
The kidney is particularly susceptible to damage by complement. Activation of the complement system is tightly regulated by a series of soluble and membrane-bound proteins. Failure of these checking mechanisms is one of the major causes of complement-mediated kidney diseases. Evidence of specific complement activity has been identified in several kidney diseases, including IgA nephropathy,...
