Grand Rounds in Transplant Nephrology – an ISN-TTS Sister Transplant Centres Initiative: Post-transplant diabetes in paediatric kidney transplant recipients
- 2 PM CET
Post transplant Diabetes (PTDM) is a well-recognized complication after Kidney transplantation. Recent updates include recognition of impaired glucose tolerance, optimization of immunosuppression, prevention of PTDM and incorporation of new glucose lowering agents. Peri-transplant hyperglycemia is being increasingly identified and treated in paediatric population. We discuss a case series of children who developed post transplant hyperglycemia. Two of them were asymptomatic, two of them had high tacrolimus levels and two of them required insulin therapy. Optimization of immunosuppression and insulin therapy resulted in resolution of hyperglycaemia.
Learning objectives:
- Describe the course of Post transplant diabetes (PTDM)
- Outline the challenges of balancing immunosuppressive medications in the presence of post-transplant hyperglycaemia
- Discuss the prevention and treatment strategies of PTDM.
Further reading:
- Adnan Sharif, Harini Chakkera, Aiko P J de Vries, Kathrin Eller et al International consensus on post-transplantation diabetes mellitus, Nephrology Dialysis Transplantation, Volume 39, Issue 3, March 2024, Pages 531–549
- Esteban L. Porrini, Armando Torres, Jose M. Díaz et al, Clinical evolution of post-transplant diabetes mellitus, Nephrology Dialysis Transplantation, Volume 31, Issue 3, March 2016, Pages 495–505
- Juan M Munoz Pena, Kenneth Cusi, Posttransplant Diabetes Mellitus: Recent Developments in Pharmacological Management of Hyperglycemia, The Journal of Clinical Endocrinology & Metabolism, Volume 109, Issue 1, January 2024, Pages e1–e11
Moderator
Rukshana Schroff (UK)
Robert Freercks (South Africa)
Speakers
Rouba Garro (USA)
Naorem Lakshmee Devi (India)
Indira Agarwal (India)