Events - Grand Rounds in Pediatric Nephrology – an ISN-IPNA Sister Centers initiative: Approach to treating lupus nephritis in children

Kidney involvement is common in lupus and the prognosis depends upon the underlying pathology and optimal and early immunosuppressive treatment. The approach should be based on kidney biopsy data, kidney function and immune tests. Different immunosuppressive regimens are indicated in pathology classes III to V based on steroids, cyclophosphamide, MMF and AZA. Monoclonal antibodies as Rituximab and Belimumab are extensively used in the last decades. The results of clinical trials and guidelines will be discussed. 

Learning objectives: 

• Diagnostic approach with an emphasis on histopathology 
• Treatment objectives and protocols 
• Evaluation of the clinical course and changing treatment modalities 
• Novel therapies for lupus nephritis