Grand Rounds in Pediatric Nephrology – an ISN-IPNA Sister Centers initiative: AKI in malaria
- 2:00 PM CEST
Malaria is a common cause of acute kidney injury (AKI) in children in low and middle income countries. AKI occurs in 24–59% of children hospitalized with severe malaria. Risk factors for malaria associated AKI include black water fever, hypovolemia, use of nephrotoxic medications and herbal medicines.
AKI is a significant predictor of both in-hospital and post discharge mortality among children with severe malaria. Among survivors, malaria associated AKI is a predictor of chronic kidney disease and neuro-cognitive dysfunction.
We present a case of 10 year old child who was hospitalized with severe malaria associated AKI. The child required dialysis during hospitalization and recovered following treatment.
We will discuss the epidemiology, risk factors, short and long-term outcomes of malaria associated AKI in children.
Learning objectives:
- Outline the epidemiology of severe malaria acute kidney injury
- Understand the pathophysiology of severe malaria associated acute kidney injury
- Discuss the risk factors for severe malaria associated acute kidney injury
- Discuss the short and long-term outcomes of severe malaria associated acute kidney injury
Further reading:
- Batte, A., Berrens, Z., Murphy, K., Mufumba, I., Sarangam, M. L., Hawkes, M. T., & Conroy, A. L. (2021). Malaria-associated acute kidney injury in African children: prevalence, pathophysiology, impact, and management challenges. International Journal of Nephrology and Renovascular Disease, 235-253.
- Namazzi, R., Batte, A., Opoka, R. O., Bangirana, P., Schwaderer, A. L., Berrens, Z., & Conroy, A. L. (2022). Acute kidney injury, persistent kidney disease, and post-discharge morbidity and mortality in severe malaria in children: a prospective cohort study. EClinicalMedicine, 44.
- Conroy, A. L., Opoka, R. O., Bangirana, P., Idro, R., Ssenkusu, J. M., Datta, D., … & John, C. C. (2019). Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria. BMC medicine, 17, 1-12.
Moderator
Arpana Iyengar (India)
Speakers
Peace Imani (USA)
Anthony Batte (Uganda)
Judith Caroline Aujo (Uganda)