Research

Expanding Skills and Knowledge in Key Areas of Kidney Care: Access Three New ISN Implementation Toolkits

As part of the ISN-WHO 2021-2023 collaboration plan, the ISN is pleased to announce the release of three new implementation toolkits. The ISN thanks all experts involved for their outstanding contributions. Acute Kidney Injury (AKI) Toolkit The toolkit facilitates AKI detection, management, and prevention, integrating key strategies highlighted in the ISN 0by25 initiative. Access here The toolkit was developed...

February 19, 2024Advocacy, News, Research, WHORead more...

“An Essential Advocacy Tool That Young Nephrologists Should Wholeheartedly Endorse”: Yannick Nlandu on the ISN-Global Kidney Health Atlas

By Yannick Nlandu (DR Congo), YNC member and  ISN-GKHA Named Fellow   Most nephrologists dream of solving kidney health problems in their communities, typically requiring a more generalist approach to public health. However, nephrology programs in general, and in low-resource countries in particular, do not integrate this broad vision of kidney health. Nephrologists, therefore, need to...

February 5, 2024News, Research, Young nephrologistsRead more...

Demystifying Global Kidney Trials: Providing Clear Explanations for All With a New ISN Patient-Focused Initiative

Discover the "ISN Global Kidney Trials Insights: A Guide for Everyone," a new ISN initiative for people living with kidney diseases and others interested in kidney-related clinical trials. The project intends to foster meaningful communication between patients and kidney care practitioners and increase patient participation in clinical trials. Read the first study in the guide comparing...

February 5, 2024News, ResearchRead more...

What is the ISN Doing About the Challenge of Chronic Kidney Disease of Unknown Origin?

Despite ongoing efforts, chronic kidney disease of unknown origin (CKDu) remains a significant, persistent challenge in several world regions. As part of its commitment to advancing equitable kidney care worldwide, the ISN launched the ISN i3C (CKDu) Network at WCN 2017 to facilitate global CKDu-related collaboration and data collection and dissemination. Explore the details of...

January 22, 2024News, ResearchRead more...

“Integral in Enabling Me to Start My Research Career”: ISN Clinical Research Program Facilitates Groundbreaking Study on Dialysis in Zimbabwe

Rumbidzai Dahwa received an ISN Clinical Research Program (CRP) grant for the research project "Prevalence of Chronic Kidney Disease in Zimbabwe" in 2017. Find out more about the CRP and how to apply here. The study, completed in 2020, was the first to provide comprehensive data on the nature and prevalence of dialysis in Zimbabwe and...

January 9, 2024Clinical Research, Grants, News, ResearchRead more...

Tackling the CKDu Puzzle: Read the ISN i3C Working Group’s Position Statement on Kidney Biopsies

Despite ongoing efforts, chronic kidney disease of unknown origin (CKDu) remains a significant, persistent problem in several world regions. The ISN i3C (CKDu) Working Group has written a comprehensive position statement offering vital guidance and recommendations for kidney biopsies in individuals suspected of CKDu. Read "Kidney Biopsies Among Persons Living in Hotspots of CKDu: A...

January 9, 2024News, ResearchRead more...

The ISN Applauds Ten New ISN-Named Fellows

Please join us in congratulating: Michele Provenzano for ISN-ACT (clinical trials) Anna Strasma for ISN i3C CKDu (chronic kidney disease of unknown origin) Winston Fung, Anukul Ghimire, Georgina Irish, Sabine Karam, Yannick Nlandu, Anna Petrova, Samveg Shah and Elliot Tannor for ISN-GKHA (Global Kidney Health Atlas) Get to know our ISN-Named Fellows here. These early-career ISN members were approved as...

December 11, 2023News, ResearchRead more...

ENVISION-ing a New Way Forward in IgA Nephropathy A Phase 2 Trial of Sibeprenlimab 

Daniel O’Hara, ISN-ACT Global Trials Focus coordinator, summarizes the design and outcomes of the latest "Trial of the Month." Explore all the global trial selections for November and December here. The "Trial of the Month" is available in several languages. A Phase 2 Trial of Sibeprenlimab in Patients With IgA Nephropathy Mathur et al., N Engl J Med...

December 11, 2023News, ResearchRead more...

Efficacy of Gravity-driven Continuous Flow Peritoneal Dialysis in Children

Rupesh Raina, ISN-ACT Global Trials Focus Subgroup member, summarizes the design and outcomes of one of the team's latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The "Trial of the month" is available in several languages. Gravity-assisted Continuous Flow Peritoneal Dialysis Technique Use in Acute Kidney Injury in Children: A...

November 27, 2023News, ResearchRead more...

Latest ISN Journal Editorial Selections

Precision medicine framework for optimizing CKD treatment Kidney International® Trends and Perspectives for Improving Quality of Chronic Kidney Disease Care: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference  The conference discussed improving chronic kidney disease (CKD) diagnosis, care safety, and patient well-being, identifying current tools, barriers, and research needs in CKD management. Discussions acknowledged that...

November 13, 2023Journals, News, ResearchRead more...

Structured Delivery of Cognitive Behavioural Therapy and Targeted Symptom Management Can Improve Fatigue, Pain and Depression Among Those on Dialysis

Daniel O’Hara, the ISN-ACT Global Trials Focus coordinator, summarizes the design and outcomes of one of the team’s latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. Effects of Technology-assisted Stepped Collaborative Care Intervention to Improve Symptoms in Patients Undergoing Hemodialysis:...

November 10, 2023News, ResearchRead more...

Letermovir Non-inferior to Valganciclovir for CMV Prophylaxis, With Lower Leukopenia Rates

ISN-ACT Global Trials Focus Subgroup member Maria Chiara Pelle summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus’ latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-risk Kidney Transplant...

October 30, 2023News, ResearchRead more...

ISN Journal Editorial Selections

Kidney International® A Prospective Controlled, Randomized Clinical Trial of Kidney Transplant Recipients Developed Personalized Tacrolimus Dosing Using Model-based Bayesian Prediction  In this study, a population pharmacokinetic (PPK) model, incorporating factors such as genetics, age, and hematocrit, was developed and validated to optimize tacrolimus (Tac) dosage for kidney transplant recipients. PPK-based dosing was compared with traditional weight-based dosing....

October 30, 2023Journals, News, ResearchRead more...

Balanced Crystalloid Fluids May Reduce Delayed Graft Function in Deceased Donor Kidney Transplantation – New Selection of Global Trials Out Now

To stay updated on the latest research and developments in kidney care, access the latest selection of global trials from the ISN-ACT initiative here in multiple languages. ISN-ACT Global Trials Focus Coordinator Michele Provenzano summarizes the design and outcomes of the ISN-ACT Global Trials Focus’ latest “Trial of the Month.” Balanced Crystalloid Solution Versus Saline in...

October 16, 2023News, ResearchRead more...

The 2023 ISN-GKHA: Shaping the Future of Kidney Health Worldwide – Access Region-specific Data and Use the Findings in Your Research

The 2023 ISN-Global Kidney Health Atlas (ISN-GKHA) is driving positive change in kidney care on a global scale, and you can play a role in this transformation! Assessing global kidney care: ISN-GKHA's comprehensive analysis for informed health policies The ISN-GKHA is a comprehensive resource offering an overview of the current readiness, capacity, and competence for kidney...

October 16, 2023News, ResearchRead more...

Use of Self-educational Materials Can Help Decrease Dietary Salt Intake in CKD Patients – Trial Summary and Commentary

Anastasiia Zykova, ISN Advancing Clinical Trials Network member, summarizes the design and outcomes of a study from the ISN-ACT Global Trials Focus' most recent global trials selection. Evaluation of a simple, low-cost intervention to empower people with chronic kidney disease to reduce their dietary salt intake: OxCKD1, a multi-center randomized controlled trial. Summary In this trial, 193 adult participants...

October 2, 2023News, ResearchRead more...

Explore the Reshaped ISN International Network of Chronic Kidney Disease Cohort Studies (iNET-CKD) Network Map

The newly updated ISN iNET-CKD Network cohorts map features a new layout, revised information on cohorts, and additional data. Access the ISN iNET-CKD Network cohorts map here. The ISN iNET-CKD Network is one-of-a-kind. It tracks ongoing chronic kidney disease (CKD) cohort studies located worldwide, facilitating an exchange of insights into CKD progression and its global implications. This network's...

September 18, 2023News, ResearchRead more...

Read the Latest ISN Journal Editorial Selections

Kidney International® Repurposing Drugs for Diseases Associated With Podocyte Dysfunction Due to recent advances in understanding the molecular and cellular mechanisms underlying podocyte injury, there is potential for repurposing already approved therapeutics for treating these disorders. This mini-review explores the complexities of repurposing drugs for kidney treatment, emphasizing the importance of extensive testing, emerging technologies, early intervention,...

September 18, 2023ELP, Journals, News, ResearchRead more...

Forewarned or Forearmed: Do Automated Medication-targeted Alerts Improve AKI Outcomes? Trial Summary and Commentary

Nikolay Bulanov, ISN-ACT Global Trials Focus Subgroup member, summarizes the design and outcomes of a study from the ISN-ACT Global Trials Focus' most recent global trials selection and comments on the trial's limitations. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes Summary: In this parallel-group, pragmatic, open-label trial, 5060 hospitalized...

September 18, 2023News, ResearchRead more...