The clinical trials workshop will be held on February 5, 2025, at the Pride Plaza Aerocity in New Delhi, India, as lead-up to the ISN World Congress of Nephrology 2025 (WCN’25) from February 6-9, 2025. It is organized by the ISN-ANIO committee, a collaboration between the ISN and the American Nephrologists of Indian Origin...
Kidney International® Outcomes From the International Society of Nephrology Hemolytic Uraemic Syndromes International Forum The 2023 ISN aHUS Forum brought together global experts to discuss key challenges in managing complement-mediated hemolytic uraemic syndromes (HUS), including nomenclature, biomarkers, and treatment protocols. Key areas for future research were identified, such as genetic predisposition, optimal complement inhibitor use, and improving...
The High-impact Trials (HIT) sessions at WCN'25 promise exciting insights and findings from cutting-edge research in kidney care and related fields, including: The FLOW Trial investigating semaglutide's impact on kidney outcomes and cardiovascular safety The REGENCY Trial on improving renal response rates in lupus nephritis with Obinutuzumab The ZEUS Trial evaluating ziltivekimab's potential for cardiovascular protection in...
This visual abstract was supported by Vera Therapeutics. Download Visual Abstract
The ISN congratulates its newest ISN-Named Fellows: Megan Borkum and Neeru Agarwal for ISN-ACT (clinical trials) Rajitha A. Abeysekera for SharE-RR (registries) Somkanya Tungsanga, Nivedita Kamath, Victoria Nkunu, Caner Alparslan, Viviane Calice-Silva, Abduzhappar Gaipov, Anna Francis and Maria Pippias, for ISN-GKHA (ISN-Global Kidney Health Atlas) Learn more about our ISN-Named Fellows here These early-career ISN members were approved as ISN-Named...
Download PDF A groundbreaking study led by ISN members as part of the Kidney Care Network (KCN) initiative has been published in PLOS Medicine. This research provides critical insights into acute kidney disease (AKD) in low- and lower-middle-income countries (LLMICs) and proposes actionable solutions to address gaps in care. Read the publication here Why this study matters AKD...
Two significant research studies were accepted as late-breaking clinical trials at Kidney Week 2024 and have subsequently been published in Kidney International®. Higher Intraoperative Blood Pressure Does Not Reduce Acute Kidney Injury in Non-Cardiac Surgery: What Do the Results of the POISE-3 Trial Tell Us? The POISE-3 trial's analysis found no benefit in targeting a...
Kidney International® A Randomized, Open-label Clinical Trial Examined the Effects of Canagliflozin on Albuminuria and eGFR Decline Using An Individual Pre-Intervention eGFR Slope The CANPIONE study showed that canagliflozin significantly reduced albuminuria by 30.8% and slowed eGFR decline in patients with type 2 diabetes and microalbuminuria. Using a novel design comparing eGFR slopes before and during treatment,...
The ISN PARADIGM meeting took place in Vancouver, BC, Canada, from November 22-23, 2024. The meeting gathered clinicians, trialists, patient partners, regulators, and industry scientists to rethink current concepts of laboratory values in chronic kidney disease (CKD) populations, the value of patient-reported outcomes, and trial designs while fostering a robust culture of clinical trials. The program...
The ISN recognizes the importance of global research initiatives in advancing its mission for equitable kidney health worldwide. To this end, it has convened several global consortia or networks to address different facets of research, including the rapidly evolving challenge of chronic kidney disease of unknown origin (CKDu). The ISN i3C (CKDu) Network (International Consortium...
The “ISN Global Kidney Trials Insights: A Guide for Everyone” has expanded to include two new case studies. Based on the ISN-ACT Global Trials Focus (GTF) summaries, the guide translates complex trial findings into accessible information to help those living with kidney diseases and others better understand advancements in kidney care. Access the simplified summaries...
Nephrology has published the paper "Structures for Quality Assurance and Measurements for Kidney Replacement Therapies: A Multinational Study From the ISN-GKHA" by Ekrikpo et al. This study evaluates the capacity for delivering quality kidney failure care globally using data from the 2023 ISN Global Kidney Health Atlas (GKHA). The findings highlight variability in quality assurance standards,...
Kidney International® NAVKIDS2: A Lesson in Matching Outcomes Measures to Interventions The Randomized Controlled Trial (NAVKIDS2) of a Patient Navigator Program Created for Children With Chronic Kidney Disease These two studies evaluate a patient navigation program for children from disadvantaged backgrounds with chronic kidney disease (CKD), aiming to improve access to evidence-based care. While the patient navigation...
Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial Kandzari et al, Circulation, 2024 Jun 11;149(24):1875-1884 ISN-ACT Global Trials Focus coordinator Megan Borkum summarizes the design and outcomes of one of the latest ISN-ACT Global Trials Focus (GTF) selections. Summary: The TARGET...
The BMJ has published the paper, "Progress of Nations in the Organisation of, and Structures for, Kidney Care Delivery Between 2019 and 2023: Cross-Sectional Survey in 148 Countries" by Okpechi et al. Using data from the ISN Global Kidney Health Atlas (GKHA) 2019 and 2023 reports, the study analyzed changes in the availability of kidney...
ISN-ACT Global Trials Focus Subgroup member Marimar Contreras Nieves summarizes the design and outcomes of one of the latest ISN-ACT Global Trials Focus (GTF) selections. The Efficacy and Safety of Sertraline in Maintenance Hemodialysis Patients With Depression: A Randomized Controlled Study Zhang et al., J Affect Disord, 2024 May, 1:353:60-66 Summary This study evaluated the efficacy and safety of...
The Nephrology Dialysis Transplantation (NDT) Supplement "Current Status of Kidney Care Services Across Countries: A Report from the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA)" presents results from the third edition of the ISN-Global Kidney Health Atlas in a curated selection of articles relevant to public policy on kidney care. The articles highlight significant...
Rare kidney diseases (RKD) place a substantial economic burden on patients and health systems, the extent of which is unknown and may be systematically underestimated by health economic techniques. The “Scoping Review of Economic Analyses of Rare Kidney Diseases,” written in collaboration with The George Institute for Global Health, examines the existing evidence base toward...
ISN-ACT Global Trials Focus editorial team member Michele Provenzano summarizes the design and outcomes of the latest "Trial of the Month" featured in ISN-ACT Global Trials Focus. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series,...
ISN-ACT Global Trials Focus contributor Ahad Qayyum summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series, selected clinical trials...
