Research

Optimize trial integrity: New SOP and ethics resources in the ISN-ACT Clinical Trials Toolkit 

The ISN-ACT Toolkit now features a section on Standard Operating Procedures (SOPs) in clinical trials to help improve clarity, consistency, and traceability in clinical trial processes.   Access the SOP section of the ISN Clinical Trials Toolkit here  Contributed by ISN-Advancing Clinical Trials Committee member Paula Andrea Marioli (Argentina) and colleagues, the section includes:  Suggested SOP format – a structured guide...

March 24, 2025News, ResearchRead more...

Explore the latest ISN-ACT Global Trials Focus selection featuring a “Trial of the Month” on the role of targeted exercises for children on hemodialysis  

ISN-ACT Global Trials Focus editorial team member Neeru Agarwal summarizes the design and outcomes of the latest "Trial of the Month" featured in ISN-ACT Global Trials Focus.   Trial of the Month:  Effect of muscle stretching and isometric exercises on quality of life in children undergoing regular hemodialysis  Khalf-Allah et al., Pediatric Nephrology. 2024 39:3289-3299.  Summary  In this single-center study, 68...

March 10, 2025News, ResearchRead more...

Global kidney health visualized: Explore the ISN-GKHA interactive map 

Launched at WCN’25, the ISN-Global Kidney Health Atlas (ISN-GKHA) interactive map is a powerful visual tool to explore comprehensive global kidney health data from the 2019 and 2023 ISN-GKHA reports. This interactive, searchable platform highlights key trends currently shaping kidney health and care with the potential to drive improvements worldwide.   Explore global kidney health...

February 24, 2025News, ResearchRead more...

PLOS articles spotlight ISN-GKHA 2023 findings on the international state of kidney care

PLOS Global Public Health recently published a series of articles using data from the third edition of the ISN-Global Kidney Health Atlas (ISN-GKHA), exploring gaps in availability, affordability, quality, and access to kidney care services across countries by World Bank income group classifications.  Read the individual papers in PLOS Global Public Health:   “Landscape of kidney replacement...

February 24, 2025News, ResearchRead more...

ISN’s Global Kidney Health Atlas 2023 Data Addresses Kidney Care Gaps in Resource-limited Settings

PLOS Global Public Health recently published a series of articles using data from the third edition of the ISN-Global Kidney Health Atlas (ISN-GKHA), exploring gaps in availability, affordability, quality, and access to kidney care services across countries by World Bank income group classifications. Read the individual papers in PLOS Global Public Health: “Landscape of Kidney Replacement...

February 12, 2025News, ResearchRead more...

Is Semaglutide a Game-changer for CKD? Insights for the Layperson Into the SMART Trial in the “Guide for Everyone”

The “ISN Global Kidney Trials Insights: A Guide for Everyone,” inspired by the ISN-ACT Global Trials Focus summaries, translates complex trial findings into accessible information. This initiative empowers people living with kidney disease and their caregivers to better understand advancements in kidney care. Access all the simplified summaries here. The latest case study features the SMART...

January 21, 2025News, ResearchRead more...

ISN Journal Summaries on Hypertension-avoidance Strategies and Age-based GFR    

Kidney International®  A Sub-study of the POISE-3 Randomized Trial Examined Effects of a Perioperative Hypotension-avoidance Strategy Versus a Hypertension-avoidance Strategy on the Risk of Acute Kidney Injury  This sub-study of the POISE-3 trial investigated whether a strategy to prevent low blood pressure during surgery could reduce the risk of acute kidney injury (AKI).   Researchers randomized 7,307 patients...

January 6, 2025Journals, News, ResearchRead more...

Celebrating ISN’s 2024 Publications: Driving Kidney Research for Better Patient Outcomes 

As we step into 2025, we reflect on the impactful ISN-led research of 2024. These studies deepen our understanding of kidney health and advance global kidney care as a health priority. Below, we highlight some of the year’s key contributions:    An Update on the Global Disparities in Kidney Disease Burden and Care Across World Countries...

January 6, 2025Journals, News, ResearchRead more...

ISN-ANIO Workshop on Global Clinical Trials in Diverse Populations – Registration Is Open!

The clinical trials workshop will be held on February 5, 2025, at the Pride Plaza Aerocity in New Delhi, India, as lead-up to the ISN World Congress of Nephrology 2025 (WCN’25) from February 6-9, 2025. It is organized by the ISN-ANIO committee, a collaboration between the ISN and the American Nephrologists of Indian Origin...

December 16, 2024News, Research, WCNRead more...

ISN Journal Editorial Selections on aHUS Management, Rituximab Therapy, Methylmalonic Acidemia, and Rare Kidney Diseases

Kidney International® Outcomes From the International Society of Nephrology Hemolytic Uraemic Syndromes International Forum  The 2023 ISN aHUS Forum brought together global experts to discuss key challenges in managing complement-mediated hemolytic uraemic syndromes (HUS), including nomenclature, biomarkers, and treatment protocols. Key areas for future research were identified, such as genetic predisposition, optimal complement inhibitor use, and improving...

December 9, 2024Journals, ResearchRead more...

Exploring Groundbreaking Research: Introducing High-impact Trials at WCN’25

The High-impact Trials (HIT) sessions at WCN'25 promise exciting insights and findings from cutting-edge research in kidney care and related fields, including: The FLOW Trial investigating semaglutide's impact on kidney outcomes and cardiovascular safety The REGENCY Trial on improving renal response rates in lupus nephritis with Obinutuzumab The ZEUS Trial evaluating ziltivekimab's potential for cardiovascular protection in...

December 9, 2024News, Research, WCNRead more...

Celebrating Excellence: Meet Eleven New ISN-Named Fellows

The ISN congratulates its newest ISN-Named Fellows: Megan Borkum and Neeru Agarwal for ISN-ACT (clinical trials) Rajitha A. Abeysekera for SharE-RR (registries) Somkanya Tungsanga, Nivedita Kamath, Victoria Nkunu, Caner Alparslan, Viviane Calice-Silva, Abduzhappar Gaipov, Anna Francis and Maria Pippias, for ISN-GKHA (ISN-Global Kidney Health Atlas) Learn more about our ISN-Named Fellows here These early-career ISN members were approved as ISN-Named...

December 9, 2024Education, News, ResearchRead more...

Results From ISN’s Kidney Care Network Published in PLOS Medicine: Advancing Acute Kidney Disease Management in Low-resource Settings 

Download PDF A groundbreaking study led by ISN members as part of the Kidney Care Network (KCN) initiative has been published in PLOS Medicine. This research provides critical insights into acute kidney disease (AKD) in low- and lower-middle-income countries (LLMICs) and proposes actionable solutions to address gaps in care.  Read the publication here  Why this study matters  AKD...

November 26, 2024Initiatives, News, ResearchRead more...

New Perspectives on Treatment Protocols: Kidney International® Publishes Late-breaking Clinical Trials

Two significant research studies were accepted as late-breaking clinical trials at Kidney Week 2024 and have subsequently been published in Kidney International®. Higher Intraoperative Blood Pressure Does Not Reduce Acute Kidney Injury in Non-Cardiac Surgery: What Do the Results of the POISE-3 Trial Tell Us?   The POISE-3 trial's analysis found no benefit in targeting a...

November 26, 2024Journals, News, ResearchRead more...

ISN Journal Editorial Selections on eGFR Decline and ADPKD Patient Perspectives

Kidney International® A Randomized, Open-label Clinical Trial Examined the Effects of Canagliflozin on Albuminuria and eGFR Decline Using An Individual Pre-Intervention eGFR Slope The CANPIONE study showed that canagliflozin significantly reduced albuminuria by 30.8% and slowed eGFR decline in patients with type 2 diabetes and microalbuminuria. Using a novel design comparing eGFR slopes before and during treatment,...

November 26, 2024Journals, News, ResearchRead more...

The ISN Holds Consensus Meeting on Changing Paradigms of Studies in CKD

The ISN PARADIGM meeting took place in Vancouver, BC, Canada, from November 22-23, 2024. The meeting gathered clinicians, trialists, patient partners, regulators, and industry scientists to rethink current concepts of laboratory values in chronic kidney disease (CKD) populations, the value of patient-reported outcomes, and trial designs while fostering a robust culture of clinical trials. The program...

November 26, 2024Initiatives, News, ResearchRead more...

Connecting Global Resources for CKDu: The ISN’s Commitment to Advancing Kidney Health Through Research

The ISN recognizes the importance of global research initiatives in advancing its mission for equitable kidney health worldwide. To this end, it has convened several global consortia or networks to address different facets of research, including the rapidly evolving challenge of chronic kidney disease of unknown origin (CKDu). The ISN i3C (CKDu) Network (International Consortium...

November 12, 2024News, ResearchRead more...

Demystifying Global Kidney Trials: Two New Case Studies in the ‘Guide for Everyone’

The “ISN Global Kidney Trials Insights: A Guide for Everyone” has expanded to include two new case studies. Based on the ISN-ACT Global Trials Focus (GTF) summaries, the guide translates complex trial findings into accessible information to help those living with kidney diseases and others better understand advancements in kidney care. Access the simplified summaries...

November 12, 2024News, ResearchRead more...