Research

Connecting Global Resources for CKDu: The ISN’s Commitment to Advancing Kidney Health Through Research

The ISN recognizes the importance of global research initiatives in advancing its mission for equitable kidney health worldwide. To this end, it has convened several global consortia or networks to address different facets of research, including the rapidly evolving challenge of chronic kidney disease of unknown origin (CKDu). The ISN i3C (CKDu) Network (International Consortium...

Demystifying Global Kidney Trials: Two New Case Studies in the ‘Guide for Everyone’

The “ISN Global Kidney Trials Insights: A Guide for Everyone” has expanded to include two new case studies. Based on the ISN-ACT Global Trials Focus (GTF) summaries, the guide translates complex trial findings into accessible information to help those living with kidney diseases and others better understand advancements in kidney care. Access the simplified summaries...

2023 ISN-GKHA Paper on Quality and Monitoring of Kidney Care Published in Nephrology

Nephrology has published the paper "Structures for Quality Assurance and Measurements for Kidney Replacement Therapies: A Multinational Study From the ISN-GKHA" by Ekrikpo et al. This study evaluates the capacity for delivering quality kidney failure care globally using data from the 2023 ISN Global Kidney Health Atlas (GKHA). The findings highlight variability in quality assurance standards,...

Latest ISN Journal Editorial Selections

Kidney International®  NAVKIDS2: A Lesson in Matching Outcomes Measures to Interventions   The Randomized Controlled Trial (NAVKIDS2) of a Patient Navigator Program Created for Children With Chronic Kidney Disease   These two studies evaluate a patient navigation program for children from disadvantaged backgrounds with chronic kidney disease (CKD), aiming to improve access to evidence-based care.   While the patient navigation...

A New Intervention for TARGETing Resistant Hypertension

Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial Kandzari et al, Circulation, 2024 Jun 11;149(24):1875-1884 ISN-ACT Global Trials Focus coordinator Megan Borkum summarizes the design and outcomes of one of the latest ISN-ACT Global Trials Focus (GTF) selections. Summary: The TARGET...

ISN-GKHA Data Highlights Progress and Challenges in Global Kidney Care Delivery: BMJ Publication  

The BMJ has published the paper, "Progress of Nations in the Organisation of, and Structures for, Kidney Care Delivery Between 2019 and 2023: Cross-Sectional Survey in 148 Countries" by Okpechi et al.   Using data from the ISN Global Kidney Health Atlas (GKHA) 2019 and 2023 reports, the study analyzed changes in the availability of kidney...

Depression Management With Sertraline in Maintenance Hemodialysis Patients

ISN-ACT Global Trials Focus Subgroup member Marimar Contreras Nieves summarizes the design and outcomes of one of the latest ISN-ACT Global Trials Focus (GTF) selections. The Efficacy and Safety of Sertraline in Maintenance Hemodialysis Patients With Depression: A Randomized Controlled Study Zhang et al., J Affect Disord, 2024 May, 1:353:60-66 Summary This study evaluated the efficacy and safety of...

ISN’s Global Kidney Health Atlas 2023 Data Highlights Kidney Care Inequalities in New Supplement Release

The Nephrology Dialysis Transplantation (NDT) Supplement "Current Status of Kidney Care Services Across Countries: A Report from the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA)" presents results from the third edition of the ISN-Global Kidney Health Atlas in a curated selection of articles relevant to public policy on kidney care. The articles highlight significant...

Investigating the Economic Burden and Cost-effectiveness Evidence Base for Rare Kidney Diseases

Rare kidney diseases (RKD) place a substantial economic burden on patients and health systems, the extent of which is unknown and may be systematically underestimated by health economic techniques. The “Scoping Review of Economic Analyses of Rare Kidney Diseases,” written in collaboration with The George Institute for Global Health, examines the existing evidence base toward...

Explore the Latest ISN Global Trials Focus Selections Featuring a “Trial of the Month” on the Effects of Semaglutide on CKD in People With Type 2 Diabetes

ISN-ACT Global Trials Focus editorial team member Michele Provenzano summarizes the design and outcomes of the latest "Trial of the Month" featured in ISN-ACT Global Trials Focus. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series,...

Should You Proceed With Surgery or Tablets in Peritoneal Dialysis Patients With Advanced Secondary Hyperparathyroidism?

ISN-ACT Global Trials Focus contributor Ahad Qayyum summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series, selected clinical trials...

Top 5 Reasons to Submit an Abstract to WCN’25

It's abstract submission season! Submitting an abstract to WCN'25 is an excellent way to showcase your research and advance your career. Find out more and submit your abstract here Here are the top 5 reasons to get motivated and submit your abstract today – think abstract, think NEPHRO! NEtworking: Cultivate lasting professional relationships Prominence: Showcase your research on...

Two New ISN Global Kidney Care Podcasts on Peritoneal Dialysis Practices and Advancing Expertise Through the Educational Ambassadors Program – Catch Up Now! 

The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is designed to advance the understanding of optimal practices for PD patients worldwide. Hear from DOPPS Program Scientific Director Roberto Pecoits-Filho in conversation with ISPD President Edwina Brown and PDOPPS International Steering Committee members Jeffrey Perl and Jenny Shen. Listen here Recorded live at WCN '24 in...

Hear From Global Experts on Equitable Access to Innovative Therapies

Aligning with the 2024 World Kidney Day theme, "Advancing equitable access to care and optimal medication practice," Nature Reviews Nephrology has published an editorial on innovative therapies for diabetic kidney disease (DKD). Five global experts* from different world regions, including authors of the 2024 World Kidney Day scientific editorial, discuss barriers that must be...

Metabolic Acidosis in CKD – to Treat or Not to Treat? Still an Unresolved Mystery

ISN-ACT Global Trials Focus contributor Sara Ksiazek summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series, selected clinical trials...

A Simple Method to Reduce Hypotension During Hemodialysis: Ascending-Descending Ultrafiltration With Linear Sodium Profiling

ISN-ACT Global Trials Focus editorial team member Dominik Tuechler summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series, selected...

Explore the Latest ISN Global Trials Focus Selection, Featuring a “Trial of the Month” on the Phase 2 Trial of Cemdisiran in Adult Patients with IgA Nephropathy

ISN-ACT Global Trials Focus editorial team member Megan Borkum summarizes the design and outcomes of the latest ISN-ACT Global Trials Focus "Trial of the Month." The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series, selected clinical trials...

New Section on Risk Matrix Available Now in the ISN-ACT Toolkit

The ISN-ACT Toolkit has been extended to include a chapter on risk management – a fundamental pillar in the planning and executing of clinical trials that helps categorize risks based on their likelihood of occurrence and potential impact on the study. This new section was contributed by ISN-Advancing Clinical Trials Committee member Dr. Paula Andrea...

Advancing #Green Nephrology: Strategies and Insights From ISN Emerging Leaders Cohorts Published in Scientific Journals 

The paper "Climate Change, Kidney Health, and Environmentally Sustainable Kidney Care" by ISN Emerging Leaders Program (ELP) cohort 2 members has been published in the Journal of the American Society of Nephrology (JASN).   Read the paper here  The cohort conducted a cross-sectional survey to:   Understand knowledge, attitudes, and practices among healthcare professionals concerning the link between climate...

Avacopan and Rituximab – A Promising Combination for Patients With ANCA-Associated Vasculitis

Read all global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. In addition, selected clinical trials are demystified for the layperson. ISN-ACT Global Trials Focus Subgroup member Nikolay Bulanov summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus’s latest trial selections. Efficacy and safety of...