Journals

ISN Journal summaries on CKD-MBD, Pexivas trial, in-center hemodialysis, and the ISN Collaborative Quality Framework on Dialysis 

Kidney International® (KI)  Chronic Kidney Disease–Mineral and Bone Disorder: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference  The 2023 KDIGO conference confirmed that the 2017 guidelines on managing chronic kidney disease–mineral and bone disorder (CKD-MBD) remain valid but proposed reframing CKD-MBD around two clinical syndromes: CKD-associated osteoporosis and CKD-associated cardiovascular disease.  Future guidelines may...

March 24, 2025Journals, NewsRead more...

ISN Journal summaries on World Kidney Day  

Kidney International® (KI)  Are Your Kidneys OK? Detect Early to Protect Kidney Health  The  World Kidney Day (WKD) editorial in Kidney International highlights the importance of early kidney disease detection to protect kidney health, slow progression, and reduce cardiovascular risk. Simple tests — serum creatinine and urine albumin — enable early diagnosis, but barriers like funding...

March 10, 2025Journals, News, World Kidney DayRead more...

ISN Journal summaries on BK polyomavirus infection and the nurse’s role in managing symptoms of dialysis recipients

Insights from the BKEVER trial comparing everolimus versus mycophenolate mofetil for BK polyomavirus infection in kidney transplant recipients The BKEVER trial compared everolimus (EVR) with mycophenolate mofetil (MMF) in kidney transplant recipients with BK polyomavirus (BKPyV) infection to assess which strategy led to faster viral clearance. Results showed that reducing MMF was more effective, with 81.3%...

February 24, 2025Journals, NewsRead more...

ISN Journal Summaries on Clinical Practice Guideline for ADPKD and Mitochondrial Function in Diabetic Kidney Disease

Kidney International® KDIGO 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD): Executive Summary The KDIGO 2025 Clinical Practice Guideline for ADPKD is the first global guideline on the evaluation, management, and treatment of this genetic disorder, focusing on areas such as diagnosis, kidney manifestations, disease progression, and extrarenal...

February 3, 2025Journals, NewsRead more...

Meet the KI-ISN Early-Career Researchers and ISN-KI Editorial Fellows!

The ISN-KI/KIR Editorial Fellows Session: The Best of 2024/25 Articles will take place at WCN’25 on Saturday, February 8, 2025, from 9:45-11:15 a.m.  KI-ISN Early-Career Researcher Awardees and ISN-KI Editorial Fellows will be honored during this session. KI-ISN Early-Career Researcher Awards honor exceptional basic and clinical science research published in Kidney International® (KI) in the...

February 3, 2025Awards, Journals, NewsRead more...

ISN Journal Summaries on Immunosuppression Treatments for Glomerular Disease and Blood Disorders With Kidney Involvement  

Kidney International® Evaluating the Risk of Cardiovascular Events Associated With Different Immunosuppression Treatments for Glomerular Diseases This study analyzed 1,912 adults with glomerular disease from Canada to evaluate the cardiovascular risks associated with immune therapies used for treatment. The findings reveal that prolonged exposure to calcineurin inhibitors and cyclophosphamide is linked to a higher risk of...

January 21, 2025Journals, NewsRead more...

ISN Journal Summaries on Hypertension-avoidance Strategies and Age-based GFR    

Kidney International®  A Sub-study of the POISE-3 Randomized Trial Examined Effects of a Perioperative Hypotension-avoidance Strategy Versus a Hypertension-avoidance Strategy on the Risk of Acute Kidney Injury  This sub-study of the POISE-3 trial investigated whether a strategy to prevent low blood pressure during surgery could reduce the risk of acute kidney injury (AKI).   Researchers randomized 7,307 patients...

January 6, 2025Journals, News, ResearchRead more...

Celebrating ISN’s 2024 Publications: Driving Kidney Research for Better Patient Outcomes 

As we step into 2025, we reflect on the impactful ISN-led research of 2024. These studies deepen our understanding of kidney health and advance global kidney care as a health priority. Below, we highlight some of the year’s key contributions:    An Update on the Global Disparities in Kidney Disease Burden and Care Across World Countries...

January 6, 2025Journals, News, ResearchRead more...

ISN Journal Editorial Selections on aHUS Management, Rituximab Therapy, Methylmalonic Acidemia, and Rare Kidney Diseases

Kidney International® Outcomes From the International Society of Nephrology Hemolytic Uraemic Syndromes International Forum  The 2023 ISN aHUS Forum brought together global experts to discuss key challenges in managing complement-mediated hemolytic uraemic syndromes (HUS), including nomenclature, biomarkers, and treatment protocols. Key areas for future research were identified, such as genetic predisposition, optimal complement inhibitor use, and improving...

December 9, 2024Journals, ResearchRead more...

New Perspectives on Treatment Protocols: Kidney International® Publishes Late-breaking Clinical Trials

Two significant research studies were accepted as late-breaking clinical trials at Kidney Week 2024 and have subsequently been published in Kidney International®. Higher Intraoperative Blood Pressure Does Not Reduce Acute Kidney Injury in Non-Cardiac Surgery: What Do the Results of the POISE-3 Trial Tell Us?   The POISE-3 trial's analysis found no benefit in targeting a...

November 26, 2024Journals, News, ResearchRead more...

ISN Journal Editorial Selections on eGFR Decline and ADPKD Patient Perspectives

Kidney International® A Randomized, Open-label Clinical Trial Examined the Effects of Canagliflozin on Albuminuria and eGFR Decline Using An Individual Pre-Intervention eGFR Slope The CANPIONE study showed that canagliflozin significantly reduced albuminuria by 30.8% and slowed eGFR decline in patients with type 2 diabetes and microalbuminuria. Using a novel design comparing eGFR slopes before and during treatment,...

November 26, 2024Journals, News, ResearchRead more...

Latest ISN Journal Editorial Selections

Kidney International® Patients With Crush Syndrome and Kidney Disease: Lessons Learned From the Earthquake in Kahramanmaraş, Türkiye This study assessed in-hospital outcomes and related factors in 1,024 adult patients diagnosed with post-earthquake crush syndrome following the 2023 earthquakes in Kahramanmaraş, Türkiye. A 9.8% mortality rate was reported. Nonsurvivors were older, were more likely to have preexisting chronic...

November 12, 2024Journals, NewsRead more...

2024 KI-ISN Early-Career Researcher Awards & 2025-2027 ISN-KI Editorial Fellowships: Apply by Dec. 19!

Calling all early-career researchers! Have you published original research in Kidney International® in 2024? Apply now for the KI-ISN Early-Career Researcher Awards and be recognized at the World Congress of Nephrology 2025. This is your chance to showcase your work and receive $500! Who can apply?  First authors of original research papers (clinical or basic/translational science) Early-career...

October 28, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections: October 2024

Kidney International® Pre-transplant Anti-nephrin Antibodies are Specific Predictors of Recurrent Diffuse Podocytopathy in the Kidney Allograft This study finds that pre-transplant anti-nephrin antibodies are strongly associated with diffuse podocytopathy recurrence after kidney transplantation. Patients with these antibodies were more likely to experience disease recurrence, while those without them were less likely. The findings suggest that testing for...

October 28, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections

Kidney International®  NAVKIDS2: A Lesson in Matching Outcomes Measures to Interventions   The Randomized Controlled Trial (NAVKIDS2) of a Patient Navigator Program Created for Children With Chronic Kidney Disease   These two studies evaluate a patient navigation program for children from disadvantaged backgrounds with chronic kidney disease (CKD), aiming to improve access to evidence-based care.   While the patient navigation...

October 14, 2024Journals, News, ResearchRead more...

Latest ISN Journal Editorial Selections

Kidney International®  Repurposing Drugs for Diseases Associated With Podocyte Dysfunction Podocyte disorders often lead to chronic kidney disease and kidney failure, with current treatments relying on nonspecific immunosuppressants that have serious side effects.   Recent advances in understanding the molecular mechanisms of podocyte injury offer new opportunities, including the potential to repurpose existing FDA-approved drugs for kidney-related uses.   This...

September 30, 2024Journals, NewsRead more...

ISN Journal Editorial Selections

Kidney International® Fluid Management Protocols in Hemodialysis Patients Using Bioimpedance Validation: Time to Look Elsewhere? This study investigated the impact of clinical protocols versus bioimpedance spectroscopy (BIS) on managing volume status in hemodialysis patients and its effect on preserving residual kidney function (RKF). The findings reveal that standardized volume management protocols achieved similar outcomes to BIS in...

September 16, 2024Journals, NewsRead more...

Latest ISN Journal Summaries on Managing Dialysis Symptoms and the 3D Virtual Reality Educational Tool DiAL-Neph

Kidney International ® Managing the Symptom Burden Associated With Maintenance Dialysis: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference The KDIGO Controversies Conference in May 2022 addressed the need for better symptom management in dialysis patients, highlighting gaps in routine symptom assessment. Key recommendations include standardizing evaluations, incorporating nonpharmacologic approaches like cognitive behavioral therapy...

September 2, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections

Kidney International® Environmental Pollution to Kidney Disease: An Updated Review of Current Knowledge and Future Directions  This review examines the growing body of research demonstrating the significant impact of environmental pollutants, especially air pollution, on the development and progression of kidney diseases. Short and long-term exposure to pollutants can lead to increased risk and progression of kidney...

July 29, 2024Journals, NewsRead more...