Journals

ISN Journal Summaries on Immunosuppression Treatments for Glomerular Disease and Blood Disorders With Kidney Involvement  

Kidney International® Evaluating the Risk of Cardiovascular Events Associated With Different Immunosuppression Treatments for Glomerular Diseases This study analyzed 1,912 adults with glomerular disease from Canada to evaluate the cardiovascular risks associated with immune therapies used for treatment. The findings reveal that prolonged exposure to calcineurin inhibitors and cyclophosphamide is linked to a higher risk of...

January 21, 2025Journals, NewsRead more...

ISN Journal Summaries on Hypertension-avoidance Strategies and Age-based GFR    

Kidney International®  A Sub-study of the POISE-3 Randomized Trial Examined Effects of a Perioperative Hypotension-avoidance Strategy Versus a Hypertension-avoidance Strategy on the Risk of Acute Kidney Injury  This sub-study of the POISE-3 trial investigated whether a strategy to prevent low blood pressure during surgery could reduce the risk of acute kidney injury (AKI).   Researchers randomized 7,307 patients...

January 6, 2025Journals, News, ResearchRead more...

Celebrating ISN’s 2024 Publications: Driving Kidney Research for Better Patient Outcomes 

As we step into 2025, we reflect on the impactful ISN-led research of 2024. These studies deepen our understanding of kidney health and advance global kidney care as a health priority. Below, we highlight some of the year’s key contributions:    An Update on the Global Disparities in Kidney Disease Burden and Care Across World Countries...

January 6, 2025Journals, News, ResearchRead more...

ISN Journal Editorial Selections on aHUS Management, Rituximab Therapy, Methylmalonic Acidemia, and Rare Kidney Diseases

Kidney International® Outcomes From the International Society of Nephrology Hemolytic Uraemic Syndromes International Forum  The 2023 ISN aHUS Forum brought together global experts to discuss key challenges in managing complement-mediated hemolytic uraemic syndromes (HUS), including nomenclature, biomarkers, and treatment protocols. Key areas for future research were identified, such as genetic predisposition, optimal complement inhibitor use, and improving...

December 9, 2024Journals, ResearchRead more...

New Perspectives on Treatment Protocols: Kidney International® Publishes Late-breaking Clinical Trials

Two significant research studies were accepted as late-breaking clinical trials at Kidney Week 2024 and have subsequently been published in Kidney International®. Higher Intraoperative Blood Pressure Does Not Reduce Acute Kidney Injury in Non-Cardiac Surgery: What Do the Results of the POISE-3 Trial Tell Us?   The POISE-3 trial's analysis found no benefit in targeting a...

November 26, 2024Journals, News, ResearchRead more...

ISN Journal Editorial Selections on eGFR Decline and ADPKD Patient Perspectives

Kidney International® A Randomized, Open-label Clinical Trial Examined the Effects of Canagliflozin on Albuminuria and eGFR Decline Using An Individual Pre-Intervention eGFR Slope The CANPIONE study showed that canagliflozin significantly reduced albuminuria by 30.8% and slowed eGFR decline in patients with type 2 diabetes and microalbuminuria. Using a novel design comparing eGFR slopes before and during treatment,...

November 26, 2024Journals, News, ResearchRead more...

Latest ISN Journal Editorial Selections

Kidney International® Patients With Crush Syndrome and Kidney Disease: Lessons Learned From the Earthquake in Kahramanmaraş, Türkiye This study assessed in-hospital outcomes and related factors in 1,024 adult patients diagnosed with post-earthquake crush syndrome following the 2023 earthquakes in Kahramanmaraş, Türkiye. A 9.8% mortality rate was reported. Nonsurvivors were older, were more likely to have preexisting chronic...

November 12, 2024Journals, NewsRead more...

2024 KI-ISN Early-Career Researcher Awards & 2025-2027 ISN-KI Editorial Fellowships: Apply by Dec. 19!

Calling all early-career researchers! Have you published original research in Kidney International® in 2024? Apply now for the KI-ISN Early-Career Researcher Awards and be recognized at the World Congress of Nephrology 2025. This is your chance to showcase your work and receive $500! Who can apply?  First authors of original research papers (clinical or basic/translational science) Early-career...

October 28, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections: October 2024

Kidney International® Pre-transplant Anti-nephrin Antibodies are Specific Predictors of Recurrent Diffuse Podocytopathy in the Kidney Allograft This study finds that pre-transplant anti-nephrin antibodies are strongly associated with diffuse podocytopathy recurrence after kidney transplantation. Patients with these antibodies were more likely to experience disease recurrence, while those without them were less likely. The findings suggest that testing for...

October 28, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections

Kidney International®  NAVKIDS2: A Lesson in Matching Outcomes Measures to Interventions   The Randomized Controlled Trial (NAVKIDS2) of a Patient Navigator Program Created for Children With Chronic Kidney Disease   These two studies evaluate a patient navigation program for children from disadvantaged backgrounds with chronic kidney disease (CKD), aiming to improve access to evidence-based care.   While the patient navigation...

October 14, 2024Journals, News, ResearchRead more...

Latest ISN Journal Editorial Selections

Kidney International®  Repurposing Drugs for Diseases Associated With Podocyte Dysfunction Podocyte disorders often lead to chronic kidney disease and kidney failure, with current treatments relying on nonspecific immunosuppressants that have serious side effects.   Recent advances in understanding the molecular mechanisms of podocyte injury offer new opportunities, including the potential to repurpose existing FDA-approved drugs for kidney-related uses.   This...

September 30, 2024Journals, NewsRead more...

ISN Journal Editorial Selections

Kidney International® Fluid Management Protocols in Hemodialysis Patients Using Bioimpedance Validation: Time to Look Elsewhere? This study investigated the impact of clinical protocols versus bioimpedance spectroscopy (BIS) on managing volume status in hemodialysis patients and its effect on preserving residual kidney function (RKF). The findings reveal that standardized volume management protocols achieved similar outcomes to BIS in...

September 16, 2024Journals, NewsRead more...

Latest ISN Journal Summaries on Managing Dialysis Symptoms and the 3D Virtual Reality Educational Tool DiAL-Neph

Kidney International ® Managing the Symptom Burden Associated With Maintenance Dialysis: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference The KDIGO Controversies Conference in May 2022 addressed the need for better symptom management in dialysis patients, highlighting gaps in routine symptom assessment. Key recommendations include standardizing evaluations, incorporating nonpharmacologic approaches like cognitive behavioral therapy...

September 2, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections

Kidney International® Environmental Pollution to Kidney Disease: An Updated Review of Current Knowledge and Future Directions  This review examines the growing body of research demonstrating the significant impact of environmental pollutants, especially air pollution, on the development and progression of kidney diseases. Short and long-term exposure to pollutants can lead to increased risk and progression of kidney...

July 29, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections

Kidney International® Long-term Impact of Immediate Versus Deferred Antiretroviral Therapy on Kidney Health in People With HIV The long-term impact of prolonged antiretroviral therapy (ART) exposure on chronic kidney disease is unknown. To investigate this, the Strategic Timing of Antiretroviral Treatment trial randomized 4,684 ART-naïve adults with CD4 cell count under 500 cells/mm3 to immediate versus deferred...

July 15, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections

Kidney International® Developing a Genetic Testing Panel for Evaluation of Morbidities In Kidney Transplant Recipients The authors developed a comprehensive gene panel to identify monogenic conditions associated with major post-transplant complications in kidney transplant recipients (KTR). They analyzed exome sequencing data from 1590 KTR and found diagnostic variants in genes linked to Mendelian kidney disorders and transplant-related...

July 1, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections

Kidney International® Cutting Back on Low-value Healthcare Practices Supports Sustainable Kidney Care This mini review, part of a collaboration between ISN Emerging Leaders Program members and Kidney International® to promote green nephrology, emphasizes the urgent need for climate action, noting that healthcare contributes 5.5% of global carbon emissions. It highlights the importance of reducing low-value care...

June 18, 2024Journals, NewsRead more...

Latest ISN Journal Editorial Selections

Kidney International® Home Dialysis:  Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference In May 2021, KDIGO held a conference on expanding home dialysis emphasizing the need for policy alignment, resources, and shared decision-making between patients, care partners, and healthcare teams to improve access and use. The conference stressed the need to advocate for...

May 21, 2024Journals, News, ResearchRead more...

Latest ISN Journal Editorial Selections

Kidney International® Improving and Maintaining Quality of Hemodialysis in Areas Conflicted by War: A Call to Action! Alasfar and colleagues discuss the severe impact of the Syrian war on kidney replacement therapy in the region, highlighting logistical challenges and compromised standards of care. They suggest key strategies to help manage kidney care in conflict areas, including understanding...

May 6, 2024Journals, News, ResearchRead more...

Latest ISN Journal Editorial Selections

Kidney International® A Toolkit for ISN’s Registry Initiative, SharE-RR This paper, led by Fergus J. Caskey, chair of the ISN SharE-RR Advisory Group, in collaboration with other SharE-RR Advisory Group members and global registry experts, introduces the ISN SharE-RR toolkit developed to assist in establishing renal registries. Access the ISN SharE-RR toolkit here The toolkit, informed by existing...

April 23, 2024Journals, NewsRead more...