News

Kidney International®

Pre-transplant Anti-nephrin Antibodies are Specific Predictors of Recurrent Diffuse Podocytopathy in the Kidney Allograft

This study finds that pre-transplant anti-nephrin antibodies are strongly associated with diffuse podocytopathy recurrence after kidney transplantation. Patients with these antibodies were more likely to experience disease recurrence, while those without them were less likely.

The findings suggest that testing for these antibodies before transplantation could help predict which patients are at higher risk for recurrence. However, further research is needed to confirm this in larger and more diverse populations.

Kidney International Reports®

A Pilot Study on Protective Effect of Ambrisentan on Proteinuria in Patients With Alport Syndrome

This pilot study evaluates the efficacy and safety of ambrisentan, a selective endothelin receptor antagonist, in patients with Alport syndrome (AS), a leading cause of kidney failure.

Results show a 23.43% reduction in proteinuria over two months with stable renal function. However, a 33% discontinuation rate due to side effects, including edema and headaches, suggests the need for close monitoring.

While promising, larger randomized trials are needed to confirm ambrisentan’s long-term safety and efficacy in AS.