Founding papers on current nephrology: from acute kidney injury to diabetic kidney disease

As part of ISN’s 60th-anniversary, Kidney International’s “Milestones in Nephrology” series highlights five significant contributions to acute kidney injury, diabetic kidney disease, and cell biology:

Glomerular hemodynamics in experimental diabetes mellitus (Hostetter TH, Troy JL, Brenner BM, 1981)

Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial (The Diabetes Control and Complications Trial (DCCT) Research Group, 1995)

Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury (Han WK, Bailly V, Abichandani R, et al. 2002)

HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney (Ryan MJ, Johnson G, Kirk J, et al. 1994)

Identification of the renal erythropoietin-producing cells using transgenic mice (Maxwell PH, Osmond MK, Pugh CW, et al. 1993)