News

The program for this symposium is almost final, and you will find the most up-to-date information on sessions and speakers on the dedicated website, CLICK HERE.

“Extrinsic” regulation of renal function by circulating hormones or nerves is critically important and has been extensively studied. “Intrinsic regulation” of renal function is equally important for the physiology and pathophysiology of the kidney. It is now apparent that a large and growing number of local factors modulate renal structure and function, including arachidonate metabolites, nucleotides, peptides, nitric oxide, reactive oxygen species, physical factors and others.

Understanding of such local regulation is rapidly evolving, including intratubular signaling, tubular-vascular interactions, regulation through the interstitium and interstitial cells, cell-cell signaling and interactions between local and circulating factors. Nonetheless, this large research field is fragmented; its perspectives and therapeutic potential will greatly benefit by a more integrated understanding.

Thus, the goal of this meeting is to bring together scientists that study intrinsic regulation of renal function or are interested in exploring its potential to identify new mechanisms and targets relevant to kidney disease. By doing so, we hope to facilitate cross-fertilization of ideas which help promote a greater and more integrative understanding of kidney function in health and in disease.

The major themes will be:

• Renal tubular lumen as a signaling compartment
• Tubulo-vascular communications
• Intercellular communication
• Autocrine and paracrine regulation of transport
• Metabolic control of kidney function

For the most up-to-date information on this ISN Forefronts Symposium, visit www.isnforefronts.org/charleston on a regular basis.